Latest Publications on TGN1412 The Yin and Yang of Immunomodulatory Biologics: Assessing the Delicate Balance between Benefit and Risk. A number of therapeutic immunomodulatory biologics, including antibodies, ... Danilenko DM, Wang H, http://dx.doi.org/10.1177/0192623311430237 Toxicol Pathol. 2012 Jan 5. In vitro cytokine release assays: reducing the risk of adverse events in man. The induction of cytokine release is a common consequence of the ... Kirton CM, Gliddon DR, Bannish G, Bembridge GP, Coney LA, http://dx.doi.org/10.4155/bio.11.272 Bioanalysis. 2011 Dec;3(23):2657-63. A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies. Human peripheral blood mononuclear cells (PBMC) are routinely used in ... Dhir V, Fort M, Mahmood A, Higbee R, Warren W, Narayanan P, Wittman V, http://dx.doi.org/10.3109/1547691X.2011.613419 J Immunotoxicol. 2012 Jan;9(1):34-42. Epub 2011 Nov 10. Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412. Human volunteers receiving TGN1412, a humanized CD28-specific monoclonal ... Romer PS, Berr S, Avota E, Na SY, Battaglia M, ten Berge I, Einsele H, Hunig T, http://dx.doi.org/10.1182/blood-2010-12-319780 Blood. 2011 Dec 22;118(26):6772-82. Epub 2011 Sep 19. Ipilimumab (Yervoy) and the TGN1412 catastrophe. The development of the anti-CTLA-4 antibody (ipilimumab; marketed as ... Bakacs T, Mehrishi JN, Moss RW, http://dx.doi.org/10.1016/j.imbio.2011.07.005 Immunobiology. 2011 Jul 7.

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